任维

学历/学位：研究生/博士

邮箱账号：renwei@snnu.edu.cn

基本信息

教授，博士生导师。主要从事强化学习神经机制的研究。兼任中国生物物理学会神经生物物理和神经信息学专业委员会、中国生理学会神经科学专业委员会、中国神经科学学会计算神经科学和神经工程专业委员会委员。

教育经历

1981-1985年，9159金沙申请大厅生物系，理学学士学位。

1985-1988年，第四军医大学生理教研室神经生理学专业，理学硕士学位。

1993-1996年，第四军医大学生理学专业神经生理学专业，理学博士学位。

工作经历

1988年-1993年，第四军医大学基础部生理教研室，讲师。

1996年-2006年，中国航天员中心，副研究员、研究员。

2006年-今，9159金沙申请大厅，教授。

主持项目

1. 国家自然科学基金面上项目

阿片样物质外周镇痛的受体机制39270247

2. 国家自然科学基金面上项目

神经元放电活动的随机自共振机制及其编码意义的研究30270432

3.国家自然科学基金面上项目

心脏起步细胞复杂自律性的非线性动力学机制 30670533

4.国家高技术发展研究计划课题

基于中枢模式发生器工作原理的自适应运动控制技术2007AA02Z310

5.国家自然科学基金面上项目

动脉压力感受器去极化阻滞的研究 30770701

研究成果

代表性论文（标注*为通讯作者）：

1. Wang L-N, Xing M-D, Qu W-T, Wang C-B, Liu Z-Q, Han J,Ren W*, Qiao Y-N*. (2022) Impaired vessel relaxation response and increased infarct size in smooth muscle cannabinoid receptor 1 knockout mice. Microvascular Research 139:104263.

2. Chang Y, Zhang J, Zhang J, Zhu W, Zheng Q, Qian Z, Wei C, Liu Y, Liu Z,Ren W, Han J*. (2022) N6-methyladenosine RNA modification of glutamatergic neurons is associated with contextual fear discrimination. Physiology & Behavior 248:113741.

3. Yao L, Li Y, Diao Z, Di Y, Wu M, Wei C, Qian Z, Liu Z, Han J, Fan J, Tian Y, Zheng Q*,Ren W*. (2021) Stress Controllability Modulates Basal Activity of Dopamine Neurons in the Substantia Nigra Compacta. eneuro 8(3):ENEURO.0044-0021.2021.

4. Xu S, Sun Y, Huang M, Huang Y, Han J, Tang X*,Ren W*. (2021) Emotional State and Feedback-Related Negativity Induced by Positive, Negative, and Combined Reinforcement. Frontiers in Psychology 12(1325)

5. Diao Z, Di Y, Wu M, Zhai C, Kang M, Li Y, Liu Y, Wei C, Zheng Q, Han J, Liu Z, Tian Y*,Ren W*. (2021) Single Exposure to Cocaine Impairs Reinforcement Learning by Potentiating the Activity of Neurons in the Direct Striatal Pathway in Mice. Neuroscience Bulletin. 37(8):1119-1134.

6.吴美霖,尧丽,李永丰,钱召强,陈乃嘉,杨海帆,郑巧华,魏春玲,韩静,田英芳,任维*. (2021)习得性无助是习得的吗？——对习得性无助理论及其反思的评述.心理科学44(2):419-425.

7. Ruan X, Fang S, Zheng Q, Qi S, Tian Y*,Ren W*. (2021) The Association between 5-Hydroxytryptamine Receptor 1B rs13212041 Polymorphism and Trait Anxiety in Chinese Han College Subjects. Life 11(9):882.

8. Diao Z, Yao L, Cheng Q, Wu M, Di Y, Qian Z, Wei C, Liu Y, Tian Y*,Ren W*. (2021) Involvement of Midbrain Dopamine Neuron Activity in Negative Reinforcement Learning in Mice. Molecular Neurobiology 58(11):5667-5681.

9. Di Y, Li Z, Li J, Cheng Q, Zheng Q, Zhai C, Kang M, Wei C, Lan J, Fan J,Ren W*, Tian Y*. (2021) Maternal folic acid supplementation prevents autistic behaviors in a rat model induced by prenatal exposure to valproic acid. Food & function 12(10):4544-4555.

10.刘颖勋*,李林源,何宇蒙,任维*. (2021)上转换纳米颗粒介导的无线光遗传学技术的研究进展.生物化学与生物物理进展48(6):646-658.

11.严传婷,杜宜楠,杜宜楠,韩静,任维,刘志强*. (2021)神经递质和调质参与盗税管周围灰质痛觉调控的研究进展.生物化学与生物物理进展48(2):158-170.

12. Wu M, Di Y, Diao Z, Yao L, Qian Z, Wei C, Zheng Q, Liu Y, Han J, Liu Z, Fan J, Tian Y*,Ren W*. (2020) Abnormal reinforcement learning in a mice model of autism induced by prenatal exposure to valproic acid. Behavioural Brain Research 395:112836.

13. Zhang J, Zhang L, Chang Y, Gu Q, Zhang J, Zhu Z, Qian Z, Wei C, Liu Z,Ren W, Han J*. (2020) The Endocannabinoid System Contributes to Memory Deficits Induced by Rapid-eye-movement Sleep Deprivation in Adolescent Mice. Neuroscience 433:174-183.

14. Yang H, Xie J, Mu W, Ruan X, Zhang J, Yao L, Diao Z, Wu M, Li Y,Ren W, Han J*. (2020) Tea polyphenols protect learning and memory in sleep-deprived mice by promoting AMPA receptor internalization. Neuroreport 31(12):857-864.

15. Shi M, Fan K, Qiao Y, Xu J, Qiu L, Li X, Liu Y, Qian Z, Wei C, Han J, Fan J, Tian Y,Ren W*, Liu Z*. (2020) Hippocampal µ-opioid receptors on GABAergic neurons mediate stress-induced impairment of memory retrieval. Molecular Psychiatry 25(5):977-992.

16. Wu Y, Fu D, Gu Q, Li Y, Qian Z, Han J, Liu Z,Ren W, Liu Y*. (2020) Activation of CB1 receptors on GABAergic interneurons in the ventrolateral orbital cortex induces analgesia. Neuroscience Letters 736:135286.

17. Yao L, Li Y, Qian Z, Wu M, Yang H, Chen N, Qiao Y, Wei C, Zheng Q, Han J, Tian Y, Liu Z,Ren W*. (2019) Loss of control over mild aversive events produces significant helplessness in mice. Behavioural Brain Research 376:112173.

18. Li Y, Zhu J, Zheng Q, Qian Z, Zhang L, Wei C, Han J, Liu Z,Ren W*. (2019) 5-HT1A autoreceptor in dorsal raphe nucleus mediates sensitization of conditioned place preference to cocaine in mice experienced with chronic pain. NeuroReport 30(9):681-687.

19. Qian Z, Wu X, Qiao Y, Shi M, Liu Z,Ren W, Han J, Zheng Q*. (2019) Downregulation of mGluR2/3 receptors during morphine withdrawal in rats impairs mGluR2/3- and NMDA receptor-dependent long-term depression in the nucleus accumbens. Neuroscience Letters 690:76-82.

20. Li Y, Zhang L, Wu Y, Zheng Q, Chen M, Qian Z, Wei C, Han J, Liu Z,Ren W, Liu Y*. (2019) Cannabinoids-induced peripheral analgesia depends on activation of BK channels. Brain Research 1711:23-28.

21. Fan K-M, Qiu L-J, Ma N, Du Y-N, Qian Z-Q, Wei C-L, Han J,Ren W, Shi M-M, Liu Z-Q*. (2019) Acute Stress Facilitates LTD Induction at Glutamatergic Synapses in the Hippocampal CA1 Region by Activating μ-Opioid Receptors on GABAergic Neurons. Frontiers in Neuroscience 13(71).

22.李永丰,任维,刘一辉*. (2019) CB1受体通过钾离子通道介导外周镇痛作用.中国病理生理杂志35(4):660-666.

23.李永丰,任维*. (2019)马钱子碱通过钾离子通道调节外周镇痛.中国疼痛医学杂志25(02):94-101.

24.李永丰,任维*(2018)外周神经压迫性损伤引起损伤区自发放电的研究概述.中国疼痛医学杂志24(12):932-937.

25. Tang XM*, Qi SQ, Wang BT, Jia XJ,Ren W*. (2017) The temporal dynamics underlying the comprehension of scientific metaphors and poetic metaphors. Brain Research 1655: 33-40

26.尧丽,杨海帆,吴美霖,李永丰,段海军,任维*. (2017)正强化和负强化:概念、争议与神经机制.心理科学40(1): 1091-1097.

27.霍清,任维,韩静*. (2017)治疗创伤后应激障碍的新靶点:内源性大麻素系统.中国病理生理杂志2017(02):375-379.

28. Ge Q, Wang Z, Wu Y, Huo Q, Qian Z, Tian Z,Ren W, Zhang X, Han J*. (2017) High salt diet impairs memory-related synaptic plasticity via increased oxidative stress and suppressed synaptic protein expression. Mol Nutr Food Res 61(10).

29. Chen M, Wang Y, Wang H,Ren W*, Wang X*. (2017) Evoking complex neuronal networks by stimulating a single neuron. Nonlinear Dynamics 88(4):2491-2501.

30.唐雪梅,任维*,胡卫平. (2016)科学语言的认知神经加工机制研究：来自ERP的证据.心理科学39(5):1071-1079.

31. Chen M,Ren W*, Wang X*. (2016) Depotentiation from Potentiated Synaptic Strength in a Tristable System of Coupled Phosphatase and Kinase. Frontiers in Computational Neuroscience 10:104.

32. Liu T, Zheng Q, Qian Z, Wang H, Liu Z,Ren W, Zhang X, Han J*. (2016) Cannabinoid-Elicited Conditioned Place Preference in a Modified Behavioral Paradigm. Biological and Pharmaceutical Bulletin 39(5):747-753.

33.李景龙,张鹏,贺健,刘红菊,任维,陈晓萍*. (2015)后肢去负荷对运动耐力变化中的影响及机制.航天医学与医学工程28(2):85-88.

34.陈梦娇,杨明浩,韩文娟,安书成,刘一辉,刘志强,任维*. (2014)主动脉弓各压力感受器分工编码不同范围的血压变化.中国科学:生命科学44(7):694-701.

35. Chen M-J, Ling H-L, Liu Y-H, Qu S-X*,Ren W*. (2014) Bifurcation diagram globally underpinning neuronal firing behaviors modified by SK conductance. Chin Phys B 23: 28701-028701.

36. Chen M, MingHao Y, WenJuan H, ShuCheng A, YiHui L, ZhiQiang L,Ren W*. (2014) Individual aortic baroreceptors are sensitive to different ranges of blood pressures. SCIENCE CHINA Life Sciences 57: 502-509.

37. Zheng Q, Liu Z*, Wei C, Han J, Liu Y, Zhang X,Ren W. (2014) Activation of the D1 receptors inhibits the long-term potentiation in vivo induced by acute morphine administration through a D1–GluN2A interaction in the nucleus accumbens. NeuroReport 25(15):1191-1197.

38.路美玲,李建宁,魏春玲,刘一辉*,任维. (2014) BK、SK通道参与慢性损伤坐骨神经异常自发放电节律的调控.9159金沙申请大厅学报（自然科学版）42(1):70-75.

39. Wu X, Shi M, Ling H, Wei C, Liu Y, Liu Z*,Ren W. (2013) Effects of morphine withdrawal on the membrane properties of medium spiny neurons in the nucleus accumbens shell. Brain Research Bulletin 90(0):92-99.

40. Wei C, Liu Y*, Yang M, Liu Z,Ren W. (2013) Dopamine Inhibits High-Frequency Stimulation-Induced Long-Term Potentiation of Intrinsic Excitability in CA1 Hippocampal Pyramidal Neurons. Neurosignals 21:150-159.

41.魏春玲,刘志强,刘一辉,任维^*. (2013)胞体高频刺激诱导VTA多巴胺能神经元兴奋性增强.生理学报65(1):55-60.

42. Han J, Kesner P, Metna-Laurent M, Duan T, Xu L, Georges F, Koehl M, Abrous Djoher N, Mendizabal-Zubiaga J, Grandes P, Liu Q, Bai G, Wang W, Xiong L,Ren W, Marsicano G,*Zhang X*. (2012) Acute Cannabinoids Impair Working Memory through Astroglial CB1 Receptor Modulation of Hippocampal LTD. Cell 148(5):1039-1050.

43. Wu X, Shi M, Wei C, Yang M, Liu Y, Liu Z*, Zhang X,Ren W. (2012) Potentiation of synaptic strength and intrinsic excitability in the nucleus accumbens after 10 days of morphine withdrawal. Journal of Neuroscience Research 90(6):1270-1283.

44.吴晓杰,张静,魏春玲,刘志强*,任维. (2012)慢性吗啡预处理减弱急性吗啡对伏隔核谷氨酸能突触传递的影响.生理学报64(2):170-176.

45.任盼,刘志强*,任维. (2012)单次可卡因注射对ＶＴＡ区ＤＡ神经元兴奋性突触传递和内在兴奋性的影响.中国药物依赖性杂志21(3):173-178.

46.卢敦国,刘一辉*,任维. (2012)单次可卡因注射对大鼠中脑腹侧被盖区多巴胺能神经元细胞兴奋性的影响.9159金沙申请大厅学报40(5):72-76.

47.李建宁,任维,刘一辉*. (2012)外周神经系统中神经微丝蛋白研究现状.山东医药52(27):88-90.

48.李建宁,刘一辉*,任维. (2012)神经病理性痛外周自发放电与钙激活钾离子通道的研究进展.广东医学33(19):3013-3015.

49.李建宁,巨文峰,钱召强,刘一辉*,任维. (2012) CCI大鼠坐骨神经损伤区内中终球与重链神经微丝蛋白的检测.生命科学研究16(3):255-259.

50.匡国晖,刘一辉*,任维. (2012) IA和Ih对鳌虾口胃神经节幽门节律的调节.生理学报64(3):275–281

51.王姗姗,魏春玲,刘志强,任维^*. (2011) L-谷氨酸和卡巴胆碱对中脑腹侧被盖区多巴胺能神经元簇放电的影响.生理学报63(1):25-30.

52.孟林伟,刘一辉*,任维. 2011.单次注射人工合成大麻素降低大鼠中脑腹侧背盖区多巴胺能神经元兴奋性.生物物理学报27(11): 948-954.

53.崔睿,王姗姗,李晋,王栋,刘一辉*,任维. 2011.由三态跃迁机制产生的两种神经放电节律.生物物理学报27(8):703-711.

54. Shi M, Wu X, Wei C, Yang M, Liu Z*,Ren W. 2011. Effects of NR2A and NR2B-containing N-methyl-D-aspartate receptors on neuronal-firing properties. NeuroReport 22(15):762-766.

55. Han J, Liu Z,Ren W, Zhang X*. 2011. Counteractive effects of cannabinoid and nicotine-addictive behavior. NeuroReport 22(4):181-184

56. Yuan L, Liu Z-Q, Zhang H-M, Ding X-L, Yang M-H, Gu H-G*,Ren W. (2011) Noise-induced synchronous stochastic oscillations in small scale cultured heart-cell networks. Chinese Physics B 20(2):020508.

57. GU H, ZHANG H, WEI C, YANG M, LIU Z,REN W*. (2011) COHERENCE RESONANCE INDUCED STOCHASTIC NEURAL FIRING AT A SADDLE-NODE BIFURCATION. International Journal of Modern Physics B 25(29):3977-3986.

58.任维. (2010)神经元兴奋动力学特性及其调节与可塑性In:唐孝威,郭爱克, editors.香山科学会议.北京 香山:科学出版社.

59.赵小燕,宋绍丽,魏春玲,古华光*,任维. (2010)神经放电节律加周期分岔序列中的簇放电到峰放电的转迁.生物物理学报26(1):61-72.

60.张磊,袁岚,杨明浩,任维,古华光*. (2010)鳌虾口胃神经节神经元簇放电的动态离子流机制.生理学报62(4):365-372.

61.宋绍丽,魏春玲,古华光,刘志强*,任维. (2010) 4-AP敏感钾通道对神经自发放电节律转迁历程的调节作用.生理学报62(1):35-41.

62.韩文娟,陈梦娇,杨明浩,古华光*,任维. (2010)脉冲激励下轴突产生兴奋后抑制现象的去极化阻滞机制的理论仿真研究.生物物理学报26(6):497-504.

63. Mo J, Li Y-Y, Wei C-L, Yang M-H,Gu H-G*, Qu S-X, Ren W. (2010) Interpreting a period-adding bifurcation scenario in neural bursting patterns using border-collision bifurcation in a discontinuous map of a slow control variable. Chinese Physics B 19(8):080513.

64. Liu Z-Q, Zhang H-M, Li Y-Y, Hua C-C, Gu H-G*,Ren W. (2010) Multiple spatial coherence resonance induced by the stochastic signal in neuronal networks near a saddle-node bifurcation. Physica A: Statistical Mechanics and its Applications 389(13):2642-2653.

65. Liu Z, Han J, Jia L, Maillet J-C, Bai G, Xu L, Jia Z, Zheng Q, Zhang W, Monette R, Merali Z, Zhu Z, Wang W,Ren W, Zhang X*. (2010) Synaptic Neurotransmission Depression in Ventral Tegmental Dopamine Neurons and Cannabinoid-Associated Addictive Learning. PLoS ONE 5(12):e15634.

66. Dong W, Juan M, Xiaoyan Z, Huaguang G*, Shixian Q,Wei R. (2010) Intermittent Chaotic Neural Firing Characterized by Non-Smooth Features Chin Phys Lett 27(7):070503.

67. Zheng Q, Liu Z, Yang M, Wu X, Gu H,Ren W*. (2009) Qualitatively different bifurcation scenarios observed in the firing of identical nerve fibers. Physics Letters A 373(5):540-545.

68. Yang M, Liu Z, Li L, Xu Y, Liu H, Gu H,Ren W*. (2009) Identifying distinct stochastic dynamics from chaos: a study on the multi-mode neural firing patterns. International Journal of Bifurcation and Chaos 19(2):453-485.

69. Zhang N, Zhang H-M, Liu Z-Q, Ding X-L, Yang M-H, Gu H-G*,Ren W. (2009) Stochastic alternating dynamics for synchronous EAD-like beating rhythms in cultured cardiac myocytes. Chinese Physics Letters 26(11):110501.

70.李玉叶,张慧敏,魏春玲,杨明浩,古华光*,任维. (2009)随机信号在神经网络中诱发的双空间相干共振.动力学与控制学报7(3):230-234.

71.丁学利,李玉叶,李群宏,古华光*,任维. (2009)神经元周期放电模式的分岔.动力学与控制学报7(4):297-301.

72. Lu Q, Yang Z, Duan L, Gu H*,Ren W. (2009) Dynamics and transitions of firing patterns in deterministic and stochastic neuronal systems. Chaos, Solitons & Fractals 40(2):577-597.

73. LI Y-Y, ZHANG H-M, WEI C-L, YANG M-H, GU H-G*,REN W. (2009) Stochastic Signal Induced Multiple Spatial Coherence Resonances and Spiral Waves in Excitable Media. Chin Phys Lett 26(3):030504.

74. Asrar S, Zhou Z,Ren W, Jia Z*. (2009) Ca2+ Permeable AMPA Receptor Induced Long-Term Potentiation Requires PI3/MAP Kinases but Not Ca/CaM-Dependent Kinase II. PLoS ONE 4(2):e4339.

75.魏春玲,古华光,杨明浩,刘志强,任维*. (2008)周期激励下FitzHugh-Nagumo模型的两种多峰分布放电节律.生物物理学报24(1):22-28.

76. Wu X-B, Mo J, Yang M-H, Zheng Q-H, Gu H-G,Ren W*. (2008) Two Different Bifurcation Scenarios in Neural Firing Rhythms Discovered in Biological Experiments by Adjusting Two Parameters. Chinese Physics Letters 25(8):2799-2802.

77.Ren W, Gu H, Yang M, Liu Z, Li L, Xu Y, Liu H. (2008) Neural Information Encoding Based on a Bifurcation Machinery. Advances in Cognitive Neurodynamics ICCN 2007: Springer press. p 821-825.

78.张慧敏,杨明浩,化存才,古华光*,任维. (2008)鞍-结分岔点附近的神经自发放电节律和随机自共振.动力学与控制学报6(4):332-335.

79. Xu Y, Li L, Yang M, Liu Z, Liu H, Gu H*,Ren W. (2007) Three Cases of the Bifurcation from Period 1 to Period 2 Bursting in Theoretical and Experimental Neural Models. Dynamics of Continuous Discrete and Impulsive Systems-Series B-Applications & Algorithms 14(S5):35-40.

80. Gu H*, Yang M, Li L,Ren W, Lu Q. (2007) Period Adding Bifurcation Scenarios with Chaotic and Stochastic Bursting in an Experimental Neural Pacemaker. Dynamics of Continuous Discrete and Impulsive Systems-Series B-Applications & Algorithms 14(S5):6-11.

81. Yang M, An S*, Gu H, Liu Z,Ren W. (2006) Understanding of physiological neural firing patterns through dynamical bifurcation machineries. Neuroreport 17(10):995-999.

82. Gu HG, Yang MH, Li L, Liu ZQ,Ren W. (2004) The chaotic and ASR induced firing patterns in an experimental neural pacemaker. Dynamics of Continuous Discrete and Impulsive Systems-Series B-Applications & Algorithms 11A:19-24.

83. Li L, Gu H, Yang M, Liu Z,Ren W*. (2004) A series of bifurcation scenarios in the firing transitions in an experimental neural pacemaker. Int J bifurcation & chaos 14(5):1813-1817.

84. Yang M, Gu H, Li L, Liu Z,Ren W*. (2003) Characteristics of period adding bifurcation without chaos in firing pattern transitions in an experimental neural pacemaker. NeuroReport 14(17):2153-2157.

85. Gu H, Yang M, Li L, Liu Z,Ren W*. (2003) Dynamics of autonomous stochastic resonance in neural period adding bifurcation scenarios. Phys Lett A 319((1-2):):89-96.

86. Gu H, Yang M, Li L, Liu Z,Ren W*. (2003) Noise induced multi-mode firing patterns in neural period adding bifurcation scenario. Int J Modern Phys B 17(22-24):4195-4200.

87. Gu H, Yang M, Li L, Liu Z,Ren W*. (2002) Experimental observation of the stochastic bursting caused by coherence resonance in a neural pacemaker. NeuroReport 13(13):1657-1660.

88.Ren W*, Gu H, Jian Z, Lu Q, Yang M. (2001) Different classifications of UPOs in the parametrically different chaotic ISI series of a neural pacemaker. NeuroReport 12(10):2121-2124.

89. Gu H,Ren W*, Lu Q, Wu S, Yang M, Chen W. (2001) Integer multiple spiking in neural pacemakers without external periodic stimulation. Phys Lett A 285:63-68.

90.Ren W, Hu SJ*, Zhang BJ, Wang FZ, Gong YF, Xu JX. (1997) Period-Adding Bifurcation with Chaos in the Interspike Intervals Generated by an Experimental Neural Pacemaker. International Journal of Bifurcation and Chaos 07(08):1867-1872.

参编书目：

1. 神经元非线性活动的探索. 胡三觉、徐建学、任维、邢俊玲、谢勇主编 科学出版社 2017

2. 数学应用工程研究. 化存才、陆启韶、任维、何树红等编著 科学出版社 2010

3.失重生理学基础与进展.沈羡云主编，任维副主编.国防工业出版社.2007